蛋白质/抗原/多肽 >> 重组蛋白
重组锌指蛋白93
半岛bd体育手机客户端 介绍
基因名:
ZNF93 半岛bd体育手机客户端 别名: HPF34; HTF34; TF34; ZNF505; ZNF93; zinc finger protein 93; zinc finger protein 93; zinc finger protein 93; zinc finger protein 505; zinc finger protein HTF34; 锌指蛋白93; 背景信息:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
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