蛋白质/抗原/多肽 >> 重组蛋白
重组GTP酶IMAP家族成员3蛋白
半岛bd体育手机客户端 介绍
基因名:
Gimap3 半岛bd体育手机客户端 别名: 2010110D23Rik; Gimap5; Ian4; Gimap3; GTPase, IMAP family member 3; GTPase, IMAP family member 3; GTPase IMAP family member 3; IAN-4; immune associated nucleotide 4; immunity-associated nucleotide 4 protein; GTP酶IMAP家族成员3; 背景信息:
GIMAP3p is a murine mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins. The human GIMAP (GTPase of the immunity-associated protein) gene family includes seven functional members residing on (human) chromosome 7q36.1 and one pseudogene (hGIMAP3).
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