蛋白质/抗原/多肽 >> 重组蛋白
重组细胞质分裂付出蛋白5
半岛bd体育手机客户端 介绍
基因名:
Dock5 半岛bd体育手机客户端 别名: 1110060D06Rik; AI666732; AI956923; BC016533; E130320D18; lr2; rlc; Dock5; dedicator of cytokinesis 5; dedicator of cytokinesis 5; dedicator of cytokinesis protein 5; lens rupture 2; lens rupture protein 2; rupture of lens cataract protein; 细胞质分裂付出蛋白5; 胞质分裂作用因子5(DOCK5); 背景信息:
DOCK 5 is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative splicing events.
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