蛋白质/抗原/多肽 >> 重组蛋白
重组抑制蛋白结构域蛋白3
半岛bd体育手机客户端 介绍
基因名:
ARRDC3 半岛bd体育手机客户端 别名: TLIMP; ARRDC3; arrestin domain containing 3; arrestin domain containing 3; arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; alpha-arrestin 3; 抑制蛋白结构域蛋白3; 背景信息:
The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.
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