蛋白质/抗原/多肽 >> 重组蛋白
重组肌动蛋白结合蛋白LIM3
半岛bd体育手机客户端 介绍
基因名:
ABLIM3 半岛bd体育手机客户端 别名: HMFN1661; ABLIM3; actin binding LIM protein family member 3; actin binding LIM protein family member 3; actin-binding LIM protein 3; abLIM-3; 肌动蛋白结合蛋白LIM3; 肌动蛋白结合蛋白LIM蛋白3; 背景信息:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.
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