蛋白质/抗原/多肽 >> 重组蛋白
重组BTB/POZ结构域蛋白3
半岛bd体育手机客户端 介绍
基因名:
BTBD3 半岛bd体育手机客户端 别名: dJ742J24.1; BTBD3; BTB domain containing 3; BTB domain containing 3; BTB/POZ domain-containing protein 3; BTB (POZ) domain containing 3; BTB/POZ结构域蛋白3; 背景信息:
BTBD3 is a 522 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD3 may play a role in transcription regulation.
标签:His-tag |
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