蛋白质/抗原/多肽 >> 重组蛋白
重组SH2结构域蛋白3A
半岛bd体育手机客户端 介绍
基因名:
SH2D3C 半岛bd体育手机客户端 别名: CHAT; NSP3; PRO34088; SHEP1; SH2D3C; SH2 domain containing 3C; SH2 domain containing 3C; SH2 domain-containing protein 3C; SH2 domain-containing Eph receptor-binding protein 1; cas/HEF1-associated signal transducer; chat-H; novel SH2-containing protein 3; SH2结构域蛋白3A; 背景信息:
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).
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