半岛bd体育手机客户端 介绍
基因名：
HUWE1 半岛bd体育手机客户端 别名： ARF-BP1； HECTH9； HSPC272； Ib772； LASU1； MRXST； MULE； URE-B1； UREB1； HUWE1； HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1； HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1； E3 ubiquitin-protein ligase HUWE1； ARF-binding protein 1； BJ-HCC-24 tumor antigen； HECT domain protein LASU1； HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase； HECT-type E3 ubiquitin transferase HUWE1； Mcl-1 ubiquitin ligase E3； URE-binding protein 1； homologous to E6AP carboxyl terminus homologous protein 9； large structure of UREB1； upstream regulatory element-binding protein 1； ADP核糖基化因子结合蛋白； 背景信息：
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
标签：His-tag |
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