蛋白质/抗原/多肽 >> 重组蛋白
重组同源结构域转录因子HESX1蛋白
半岛bd体育手机客户端 介绍
基因名:
HESX1 半岛bd体育手机客户端 别名: ANF; CPHD5; RPX; HESX1; HESX homeobox 1; HESX homeobox 1; homeobox expressed in ES cells 1; Rathke pouch homeobox; homeobox protein ANF; 同源结构域转录因子HESX1; 背景信息:
The homeobox protein, HESX1, which is also known as Rathke’s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays.
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