蛋白质/抗原/多肽 >> 重组蛋白
重组Fcγ免疫球蛋白IgG结合
半岛bd体育手机客户端 介绍
基因名:
FCGBP 半岛bd体育手机客户端 别名: FC(GAMMA)BP; FCGBP; Fc gamma binding protein; Fc gamma binding protein; IgGFc-binding protein; Fc fragment of IgG binding protein; Human Fc gamma BP; IgG Fc binding protein; fcgamma-binding protein antigen; fcgammaBP; Fcγ免疫球蛋白IgG结合蛋白; IgG-Fc片段结合蛋白(FcgBP); 背景信息:
Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum.
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