蛋白质/抗原/多肽 >> 重组蛋白
重组紧密连接蛋白MUPP1
半岛bd体育手机客户端 介绍
基因名:
MPDZ 半岛bd体育手机客户端 别名: HYC2; MUPP1; MPDZ; multiple PDZ domain crumbs cell polarity complex component; multiple PDZ domain crumbs cell polarity complex component; multiple PDZ domain protein; multi-PDZ domain protein 1; 紧密连接蛋白MUPP1; 背景信息:
MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.
标签:His-tag |
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