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凋亡加强结构域蛋白15样蛋白抗体
半岛bd体育手机客户端 介绍
靶标：
NLRC3 半岛bd体育手机客户端 别名： CLR16.2； NOD3； NLRC3； NLR family CARD domain containing 3； NLR family CARD domain containing 3； NLR family CARD domain-containing protein 3； CARD15-like protein； NACHT, LRR and CARD domains-containing protein 3； NOD-like receptor C3； caterpiller protein 16.2； nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3； 凋亡加强结构域蛋白15样蛋白； 背景信息：
NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-κB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
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