半岛bd体育手机客户端 介绍
靶标：
U2AF1L4 半岛bd体育手机客户端 别名： U2AF1-RS3； U2AF1L3； U2AF1L3V1； U2AF1RS3； U2af26； U2AF1L4； U2 small nuclear RNA auxiliary factor 1 like 4； U2 small nuclear RNA auxiliary factor 1 like 4； splicing factor U2AF 26 kDa subunit； U2 auxiliary factor 26； U2 small nuclear RNA auxiliary factor 1-like 3； U2 small nuclear RNA auxiliary factor 1-like protein 3； U2 small nuclear RNA auxiliary factor 1-like protein 4； U2(RNU2) small nuclear RNA auxiliary factor 1-like 3； U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3； U2AF1-like 4； U2AF1-like protein 3； 背景信息：
U2AF1L4 is a RNA-binding protein that function as a pre-mRNA splicing factor. It plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It acts by enhancing the binding of U2AF2 to weak pyrimidine tracts and also participates in the regulation of alternative pre-mRNA splicing. It activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. U2AF1L4 binds to RNA at the AG dinucleotide at the 3'-splice site.
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