闈舵爣锛欬p style="text-indent: 2em;">U2AF1L4

浜у搧鍒悕锛欬p style="text-indent: 2em;">U2AF1-RS3锛 U2AF1L3锛 U2AF1L3V1锛 U2AF1RS3锛 U2af26锛 U2AF1L4锛 U2 small nuclear RNA auxiliary factor 1 like 4锛 U2 small nuclear RNA auxiliary factor 1 like 4锛 splicing factor U2AF 26 kDa subunit锛 U2 auxiliary factor 26锛 U2 small nuclear RNA auxiliary factor 1-like 3锛 U2 small nuclear RNA auxiliary factor 1-like protein 3锛 U2 small nuclear RNA auxiliary factor 1-like protein 4锛 U2(RNU2) small nuclear RNA auxiliary factor 1-like 3锛 U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3锛 U2AF1-like 4锛 U2AF1-like protein 3锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">U2AF1L4 is a RNA-binding protein that function as a pre-mRNA splicing factor. It plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It acts by enhancing the binding of U2AF2 to weak pyrimidine tracts and also participates in the regulation of alternative pre-mRNA splicing. It activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. U2AF1L4 binds to RNA at the AG dinucleotide at the 3'-splice site.