半岛bd体育手机客户端 介绍
靶标：
PRDM9 半岛bd体育手机客户端 别名： KMT8B； MEISETZ； MSBP3； PFM6； ZNF899； PRDM9； PR/SET domain 9； PR/SET domain 9； histone-lysine N-methyltransferase PRDM9； PR domain 9； PR domain containing 9； PR domain zinc finger protein 9； [histone H3]-lysine36 N-trimethyltransferase PRDM9； [histone H3]-lysine4 N-trimethyltransferase PRDM9； [histone H3]-lysine9 N-trimethyltransferase PRDM9； [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9； [histone H4]-lysine20 N-methyltransferase PRDM9； histone methyl transferase； minisatellite binding protein 3 (115kD)； protein-lysine N-methyltransferase PRDM9； 背景信息：
The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described.
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