半岛bd体育手机客户端 介绍
靶标：
METTL13 半岛bd体育手机客户端 别名： 5630401D24Rik； CGI-01； DFNB26； DFNB26M； DFNM1； EEF1AKNMT； KIAA0859； feat； METTL13； methyltransferase 13, eEF1A lysine and N-terminal methyltransferase； methyltransferase 13, eEF1A lysine and N-terminal methyltransferase； eEF1A lysine and N-terminal methyltransferase； antiapoptotic protein FEAT； deafness (autosomal recessive, nonsyndromic) modifier 1； deafness (recessive, non-syndromic) modifier 1； deafness (recessive, nonsyndromic) modifier 1； eEF1A-KNMT； faint expression in normal tissues, aberrant overexpression in tumors； methyltransferase like 13； methyltransferase-like protein 13； KIAA0859蛋白； 背景信息：
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2 at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6.
宿主：Rbt |
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