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信号转导蛋白9复合体7b抗体
半岛bd体育手机客户端 介绍
靶标：
Cops7b 半岛bd体育手机客户端 别名： D1Wsu66e； E130114M23； Cops7b； COP9 signalosome subunit 7B； COP9 signalosome subunit 7B； COP9 signalosome complex subunit 7b； COP9 (constitutive photomorphogenic) homolog, subunit 7b； COP9 complex S7b； JAB1-containing signalosome subunit 7b； SGN7b； signalosome subunit 7b； 信号转导蛋白9复合体7b； 背景信息：
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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