半岛bd体育手机客户端
介绍 靶标： TRPC4AP 半岛bd体育手机客户端 别名： C20orf188； PPP1R158； TRRP4AP； TRUSS； TRPC4AP； transient receptor potential cation channel subfamily C member 4 associated protein； transient receptor potential cation channel subfamily C member 4 associated protein； short transient receptor potential channel 4-associated protein； TNF-receptor ubiquitous scaffolding/signaling protein； TRP4-associated protein； protein phosphatase 1, regulatory subunit 158； trpc4-associated protein； tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein； 背景信息： TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein), also known as TRUSS or TRRP4AP, is a 797 amino acid protein that is expressed in a variety of tissues, with highest expression in liver, heart, testis and brain. Thought to function as a scaffolding protein, TRPC4AP interacts with TNF-R1 and may both link TNF-R1 to the IKK signalsome complex, and participate in the activation of NFκB p50, an event that occurs in response to TNF-R1 ligation. TRPC4AP exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. 宿主：Rbt |
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