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减数分裂重组11同源物A(MRE11A)抗体
半岛bd体育手机客户端 介绍
靶标:
Mre11a 半岛bd体育手机客户端 别名: Mre11; Mre11b; Mre11a; MRE11A homolog A, double strand break repair nuclease; MRE11A homolog A, double strand break repair nuclease; double-strand break repair protein MRE11; MRE11 homolog 1; MRE11 homolog A; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A; 减数分裂重组11同源物A(MRE11A); 背景信息:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
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