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乳腺肿瘤病毒受体同源蛋白抗体
半岛bd体育手机客户端 介绍
靶标:
Fam89b 半岛bd体育手机客户端 别名: 1110021A21Rik; MMTV; Mtvr2; Fam89b; family with sequence similarity 89, member B; family with sequence similarity 89, member B; leucine repeat adapter protein 25; C184L ORF2 protein; C184M protein; MMTV receptor; mammary tumor virus receptor 2; protein FAM89B; 乳腺肿瘤病毒受体同源蛋白; 背景信息:
Mtvr1 (mammary tumor virus receptor homolog 1), also known as FAM89B (family with sequence similarity 89, member B), is a 176 amino acid protein that exists as two alternatively spliced isoforms. Belonging to the FAM89 family, Mtvr1 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
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