基本信息

分子式	C9H11N2Na2O8P
分子量	352.15
MDL编码	MFCD00065282
EINECS 编号	255-687-1
存储条件	Freezer -20℃

一般描述

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

应用

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay.to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen.in thymidylate synthase activity assay Helicobacter pylori.

生化/生理作用

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
TSCA	否