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Pimelic Diphenylamide 106

品牌
J&K
CAS
937039-45-7
货号
2286670
规格纯度
98%, 一种缓慢的, 结合紧密的I类HDAC抑制剂,(抑制HDAC1, 2和3, IC50值分别150 nM, 760nM, 和370 nM), 对II类HDAC没有活性
价格
684 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
937039-45-7
Pimelic Diphenylamide 106
RGFA-8, TC-H 106, Histone Deacetylase Inhibitor VII
半岛bd体育手机客户端 介绍:

基本信息

分子式 C20H25N3O2
分子量 339.43
存储条件 Freezer -20℃

半岛bd体育手机客户端 描述

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2) Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

靶点(IC50 & Targe)

HDAC

参考文献

[1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

[2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

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