Pimelic Diphenylamide 106

半岛bd体育手机客户端名称：

937039-45-7
Pimelic Diphenylamide 106
RGFA-8, TC-H 106, Histone Deacetylase Inhibitor VII

半岛bd体育手机客户端介绍：

基本信息

分子式	C₂₀H₂₅N₃O₂
分子量	339.43
存储条件	Freezer -20℃

半岛bd体育手机客户端描述

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2) Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

靶点（IC50 & Targe）

HDAC

参考文献

[1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

[2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.