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重组胃癌多药耐药相关蛋白
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介绍 基因名: CAPRIN2 半岛bd体育手机客户端 别名: C1QDC1; EEG-1; EEG1; RNG140; CAPRIN2; caprin family member 2; caprin family member 2; caprin-2; C1q domain-containing protein 1; RNA granule protein 140; cytoplasmic activation/proliferation-associated protein 2; gastric cancer multidrug resistance-associated protein; 胃癌多药耐药相关蛋白; 背景信息: Caprin2 is 1127 amino acid highly conserved protein that is ubiquitously expressed with highest levels of expression in brain and spleen. Caprin2 stabilizes cytosolic β-catenin and enhances LEF-1 dependent reporter gene activity as well as the expression of Wnt target genes in mammalian cells. Caprin2 promotes LRP5/6 phosphorylation by GSK-3 and enhances the interaction between Axin and LRP5/6. It is suggested that Caprin2 functions as a proapoptotic inhibitor of the cell cycle. Nine isoforms of Caprin2 exist due to alternative splicing events. 标签:His-tag |
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