蛋白质/抗原/多肽 >> 重组蛋白
重组PERQ1蛋白
半岛bd体育手机客户端 介绍
基因名：
Gigyf1 半岛bd体育手机客户端 别名： Perq1； mKIAA4110； Gigyf1； GRB10 interacting GYF protein 1； GRB10 interacting GYF protein 1； GRB10-interacting GYF protein 1； GRB10 interacting GYF protein 2； PERQ amino acid rich, with GYF domain 1； PERQ amino acid-rich with GYF domain-containing protein 1； PERQ1蛋白； 背景信息：
PERQ1 is a 1,035 amino acid phosphoprotein that contains one GYF domain and belongs to the PERQ family. Ubiquitously expressed, PERQ1 exhibits highest expression in brain and lung, followed by heart, spleen and kidney. PERQ1 contains a GYF domain in its N-terminal half and a clathrin light chain homology domain in its C-terminal half. PERQ1 interacts with GRB10, with transient binding increased under IGF-I stimulation, thereby leading to recruitment of the PERQ1/GRB10 complex to the IGF-I receptor. PERQ1 may also increase IRS-1, Shc and IGF-I receptor phosphorylation during IGF-I stimulation, and may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling.
标签：His-tag |
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