半岛bd体育手机客户端
介绍 靶标: DPH1 半岛bd体育手机客户端 别名: DEDSSH; DPH2L; DPH2L1; OVCA1; DPH1; diphthamide biosynthesis 1; diphthamide biosynthesis 1; 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; DPH-like 1; DPH1 homolog; DPH2-like 1; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1; candidate tumor suppressor in ovarian cancer 1; diphthamide biosynthesis protein 1; diphthamide biosynthesis protein 2 homolog-like 1; diphtheria toxin resistance protein 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; ovarian cancer-associated gene 1 protein; ovarian tumor suppressor candidate 1; 卵巢癌相关基因1; 背景信息: OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2. 宿主:Rbt |
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