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AUH抗体
半岛bd体育手机客户端 介绍
靶标：
AUH 半岛bd体育手机客户端 别名： AUH； AU RNA binding methylglutaconyl-CoA hydratase； AU RNA binding methylglutaconyl-CoA hydratase； methylglutaconyl-CoA hydratase, mitochondrial； 3-MG-CoA hydratase； 3-methylglutaconyl-CoA hydratase； AU RNA binding protein/enoyl-CoA hydratase； AU RNA-binding protein/enoyl-Coenzyme A hydratase； AU-binding protein/Enoyl-CoA hydratase； AU-specific RNA-binding enoyl-CoA hydratase； itaconyl-CoA hydratase； 背景信息：
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants.
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