Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator ofAMPA receptor(an AMPA potentiator) with anEC₅₀of 310 nM and aK_iof 170 nM^[1].

Pesampator (0.1-1 mg/kg; SC) dose-dependently increases CD-1 mouse cerebellum cGMP and Pesampator (0.1-0.32 mg/kg; SC) decreases fall latency in C57BL/6J mice traversing an accelerating rotarod^[1].
Pesampator (0.001-0.01 mg/kg; male Sprague-Dawley rats) reverses the MK-801-mediated (0.05 mg/kg; IV) reduction in paired-pulse facilitation (PPF) after cumulative or a single (0.01 mg/kg) intravenous dose^[1].
Pesampator (0.0032–0.032 mg/kg; SC) attenuates ketamine-induced working memory disruptions in rats as determined by mean errors in a radial arm maze^[1].
In rats, Pesampator (0.027, 0.08, and 0.60 mg/kg; SC) dose-dependently affectes the regional brain uptake of 2-deoxy-2-[^18F]fluoro-d-glucose (FDG)^[1].

392.49

Solid

C₁₈H₂₀N₂O₄S₂

1258963-59-5

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(254.78 mM;Need ultrasonic)

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