Cimpuciclib tosylate is a selectiveCDK4inhibitor (IC₅₀: 0.49 nM) that has anti-tumor activity^[1].

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells^[1].

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice^[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma^[1].

Animal Model:	Colo205 tumor-bearing mice[1]
Dosage:	50 mg/kg, twice a week
Administration:	Oral gavage
Result:	Inhibited tumor growth by 93.63%

Animal Model:	Rats, colo205 tumor-bearing mice[1]
Dosage:	5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:	Oral administration
Result:	Pharmacokinetic profile of Cimpuciclib (example 63). dose Cmax(ng/mL) Tmax(h) AUC0-24(ng/mLoh) t1/2(h) 5 mg/kg (rats) 559.7 6 5414 2.4 50 mg/kg (mice) 7960 1 136782 14.8 map

714.85

Solid

C₃₇H₄₃FN₈O₄S

2408872-84-2

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 200 mg/mL(279.78 mM;Need ultrasonic)

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。