| Cas No. | 145773-22-4 |
| 别名 | 15(S)-拉坦前列素 |
| Canonical SMILES | O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CC[C@H](O)CCC2=CC=CC=C2)[C@H](O)C1 |
| 分子式 | C26H40O5 |
| 分子量 | 432.6 |
| 溶解度 | DMF: 100 mg/ml,DMSO: 100 mg/ml,DMSO:PBS (1:12): 80 µ g/ml,Ethanol: 100 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product. |
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