GNE-2256 (molecule 19) is an orally activeIRAK4(Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4K_i=1.4 nM;IL-6IC₅₀=190 nM)^[1].

GNE-2256 (3 mg/kg) shows inhibition of IL-6, TNFα, and IFNα secretion in R848-induced mouse PD model^[1].

482.51

C₂₄H₂₇FN₆O₄

2102170-43-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.