ATC0175 is a potent, selective and orally activemelanin-concentrating hormone 1 recepterantagonist withIC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders^[1].

IC₅₀: 13.5 nM (MCH1R); >10000 nM (MCH2R)^[1].

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC₅₀s of 9.66 and 16.9 nM respectively^[1].

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential^[1].

461.94

C₂₃H₂₆ClF₂N₅O

510733-97-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.