Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropicGABA_Breceptor (GABA_BR)agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_Breceptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research^[1][2][3].

Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells^[3].

Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice^[3].

213.66

Solid

C₁₀H₁₂ClNO₂

1134-47-0

巴氯芬；氯苯氨丁酸

Room temperature in continental US; may vary elsewhere.

H₂O : 2 mg/mL(9.36 mM;Need ultrasonic)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 2.5 mg/mL (11.70 mM); Clear solution; Need ultrasonic and warming and heat to 60℃