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Teverelix
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Teverelix图片
CAS NO:151272-78-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

半岛bd体育手机客户端 名称
EP 24332
半岛bd体育手机客户端 介绍
Teverelix (EP 24332) 是一种GnRH拮抗剂。Teverelix 可竞争性和可逆性地与 GnRH 受体 (GnRH receptors)结合，从而抑制 LH 和 FSH 的释放。Teverelix 可用于前列腺增生、子宫内膜异位症和前列腺癌的研究。
生物活性

Teverelix (EP 24332) is aGnRHantagonist. Teverelix binds competitively and reversibly toGnRH receptors, thereby suppressing the release of LH andFSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostatecancer[1][2].

体外研究
(In Vitro)

Teverelix (10 nM, 45 mins) inhibits GnRH-induced intracellular Ca2+increase in HEK293/GnRHR cells[2].
Teverelix (0.1 nM-1 μM, 45 mins) inhibits GnRH-induced cAMP accumulation in HEK293/GnRHR cells[2].
Teverelix (10 nM-1 μM, 15 mins) inhibits GnRH-induced pERK1/2 and pCREB activation in HEK293/GnRHR cells[2].
Teverelix inhibits histamine release in a peritoneal rat mast cell, with an EC50value of 81 μg/mL[3].

Western Blot Analysis[2]

Cell Line:HEK293/GnRHR cells
Concentration:10 nM, 100 nM, 1 μM
Incubation Time:15 mins
Result:Inhibited GnRH-induced pERK1/2 and pCREB activation.
体内研究
(In Vivo)

Teverelix (3-300 μg/kg, intramuscular injection) inhibits testosterone in rats[3].
Teverelix (1 mg/kg, s.c, daily for 3 days) abolishes luteal function in stumptailed macaques[4].

Animal Model:Rats[3]
Dosage:300, 100, 30, 10 and 3 μg/kg
Administration:Intramuscular injection
Result:Showed dose-response and time-course of testosterone inhibitory activity.
Clinical Trial
分子量

1459.13

Formula

C74H100ClN15O14

CAS 号

151272-78-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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