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MONNA
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MONNA图片
CAS NO:1572936-83-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

半岛bd体育手机客户端 介绍
MONNA 是一种有效的跨膜蛋白 16A (TMEM16A, Anoctamin-1) 阻断剂,IC50 为 80 nM。
Cas No.1572936-83-4
别名2-(4-甲氧基萘-2-基氨基)-5-硝基苯甲酸
化学名2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Canonical SMILESCOC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=CC=CC=C31
分子式C18H14N2O5
分子量338.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述 MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 uM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 uM. MONNA (10 uM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.
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