19,20-Epoxycytochalasin D 是一种细胞松弛素,是一种来自 Nemania sp. 的真菌代谢物。
Cas No. | 191349-10-7 |
别名 | 19,20-环氧细胞松弛素D |
Canonical SMILES | O=C1[C@@](O)(C)[C@H](O2)[C@@H]2[C@@H](OC(C)=O)[C@]3([C@](/C=C/C[C@@H]1C)([H])[C@@H]4O)[C@@]([C@H](CC5=CC=CC=C5)NC3=O)([H])[C@H](C)C4=C |
分子式 | C30H37NO7 |
分子量 | 523.6 |
溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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描述 | 19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. |