PD 128907 HCl - 半岛电竞官方网址

Molecular Weight (MW)	285.77
Formula	C14H19NO3.HCl
CAS No.	112960-16-4
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 12 mg/mL (42.0 mM)
Water: 50 mg/mL (175.0 mM)
Ethanol: <1 mg/mL
Other info	Chemical Name: (4aS,10bS)-4-Propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol Hydrochloride InChi Key: DCFXOTRONMKUJB-KYSPHBLOSA-N InChi Code: InChI=1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m0./s1 SMILES Code: OC1=CC([C@]2([H])OCCN(CCC)[C@@]2([H])CO3)=C3C=C1.[H]Cl
Synonyms	PD 128907 HCl; PD128907 HCl; PD-128907 HCl; (+)-PD 128907 HCl; (+)-PD-128907 HCl; (+)-PD128907 HCl; (+)-PD128907 hydrochloride; (+)-PD-128907 hydrochloride; (+)-PD 128907 hydrochloride; PBPO; PBTO;

Molecular Weight (MW)

285.77

Formula

C14H19NO3.HCl

CAS No.

112960-16-4

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 12 mg/mL (42.0 mM)

Water: 50 mg/mL (175.0 mM)

Ethanol: <1 mg/mL

Other info

Chemical Name: (4aS,10bS)-4-Propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol Hydrochloride
InChi Key: DCFXOTRONMKUJB-KYSPHBLOSA-N
InChi Code: InChI=1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m0./s1
SMILES Code: OC1=CC([C@]2([H])OCCN(CCC)[C@@]2([H])CO3)=C3C=C1.[H]Cl

Synonyms

PD 128907 HCl; PD128907 HCl; PD-128907 HCl; (+)-PD 128907 HCl; (+)-PD-128907 HCl; (+)-PD128907 HCl; (+)-PD128907 hydrochloride; (+)-PD-128907 hydrochloride; (+)-PD 128907 hydrochloride; PBPO; PBTO;

In Vitro	In vitro activity: PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM). PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release. Kinase Assay: (+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D3 receptors, 179, 770 n M for human and rat D3 receptors, respectively.
In Vivo	PD 128907 is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. PD 128907 (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling.
Animal model	Mouse
Formulation & Dosage	Dissolved in water; 3 mg/kg; i.p. injection
References	Neuroreport. 1995 Jan 26;6(2):329-32; J Pharmacol Exp Ther. 2004 Mar;308(3):957-64.

In Vitro

In vitro activity: PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM). PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.

Kinase Assay: (+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D3 receptors, 179, 770 n M for human and rat D3 receptors, respectively.

In Vivo

PD 128907 is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. PD 128907 (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling.

Animal model

Mouse

Formulation & Dosage

Dissolved in water; 3 mg/kg; i.p. injection

References

Neuroreport. 1995 Jan 26;6(2):329-32; J Pharmacol Exp Ther. 2004 Mar;308(3):957-64.

CAS NO:	112960-16-4
规格:	≥98%

包装	价格(元)
2mg	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
250mg	电议
500mg	电议