| CAS NO: | 63208-82-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 367.3 |
|---|---|
| Formula | C16H18N2OS.HBr |
| CAS No. | 63208-82-2 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 67 mg/mL (182.41 mM) |
| Water:<1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: 2 mg/mL (6.08 mM) | |
| Solubility (In vivo) | 30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| SMILES Code | CC1=CC=C(C(CN2C(SC3=C2CCCC3)=N)=O)C=C1.[H]Br |
| Synonyms | Pifithrin-alpha; Pifithrin alpha; PFTalpha; PFTalpha; PFT alpha |
| General | Pifithrin-α (2.2 mg/kg i.p.) treatment completely rescues mice (C57BL and Balb/c) of both strains from 60% killing doses of gamma irradiation (8 Gy for C57BL and 6 Gy for Balb/c). Pifithrin-α-injected mice lost less weight than irradiated mice that are not pretreated with the Pifithrin-α. Pifithrin-α (2.2 mg/kg) abrogates p53-dependent regulation of DNA replication after whole-body gamma irradiation in mice. |
|---|---|
| Animal model | C57BL and Balb/c mice |
| Formulation | Dissolved in Saline |
| Dosages | 2.2 mg/kg |
| Administration | i.p |
| References | [1] Komarov PG, et al. Science, 1999, 285(5434), 1733-1737. |
IS upregulates α-SMA protein through p53 and ROS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7. | IS induces activated p53 expression, which is involved in suppression of serum-induced proliferation of HK-2 cells caused by IS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7. | IS-induced HK-2 cell senescence is inhibited by PFTα. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7. |
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