PD 174265 是一种有效的、细胞可渗透的、可逆的、选择性的 EGFR 抑制剂，IC50 为 450 pM。
| Cas No. | 216163-53-0 |
| Canonical SMILES | BrC1=CC(NC2=NC=NC3=C2C=C(NC(CC)=O)C=C3)=CC=C1 |
| 分子式 | C17H15BrN4O |
| 分子量 | 371.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity. |
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