BRD4884 是一种有效的 HDAC 抑制剂，对 HDAC1、2 和 3 的 IC50 值分别为 29 nM、62 nM 和 1.09 μM。
| Cas No. | 1404559-91-6 |
| Canonical SMILES | FC1=CC=C(C2=CC=C(N)C(NC(C3CCOCC3)=O)=C2)C=C1 |
| 分子式 | C18H19FN2O2 |
| 分子量 | 314.4 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 2 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min versus 20 min). BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. |
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