| Cas No. | 75504-34-6 |
| 别名 | 他莫昔芬N-氧化物 |
| Canonical SMILES | CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)(C)=O)C=C3 |
| 分子式 | C26H29NO2 |
| 分子量 | 387.5 |
| 溶解度 | DMF: 20 mg/mL,DMSO: 2 mg/mL,Ethanol: 20 mg/mL,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent compound, tamoxifen N-oxide can form DNA adducts. Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 µM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively). |
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