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Napyradiomycin A1
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Napyradiomycin A1图片
CAS NO:103106-24-7
包装:1mg
市场价:2344元

半岛bd体育手机客户端 介绍
Napyrradiomycin A1 是 Napyradiomycins 的一种对映选择性化合物。
Cas No.103106-24-7
Canonical SMILESOC1=CC(O)=C2C(C([C@@](OC(C)(C)[C@H](Cl)C3)(C/C=C(C)/CC/C=C(C)/C)[C@@]3(Cl)C2=O)=O)=C1
分子式C25H30Cl2O5
分子量481.4
溶解度Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 µg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 µM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively).3

1.Shiomi, K., Iinuma, H., Hamada, M., et al.Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activityJ. Antibiot. (Tokyo)39(4)487-493(1986) 2.Hori, Y., Abe, Y., Shigematsu, N., et al.Napyradiomycins A and B1: Non-steroidal estrogen-receptor antagonists produced by a StreptomycesJ. Antibiot. (Tokyo)46(12)1890-1893(1993) 3.Yamamoto, K., Tashiro, E., Motohashi, K., et al.Napyradiomycin A1, an inhibitor of mitochondrial complexes I and IIJ. Antibiot. (Tokyo)65(4)211-214(2012)

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