| CAS NO: | 1127298-67-2 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1127298-67-2 |
| 别名 | 奥美沙坦酯 d6 |
| Canonical SMILES | CCCC1=NC(C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])=C(C(OCC(O2)=C(C)OC2=O)=O)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3 |
| 分子式 | C29H24D6N6O6 |
| 分子量 | 564.6 |
| 溶解度 | DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | Olmesartan medoxomil-d6is intended for use as an internal standard for the quantification of olmesartan medoxomil by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan , a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2receptor.1Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day.2Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension. 1.Mizuno, M., Sada, T., Ikeda, M., et al.Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonistEur. J. Pharmacol.285(2)181-188(1995) 2.Okada, K., Hirano, T., Ran, J., et al.Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed ratsHypertens. Res.27(4)293-299(2004) |
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