生物活性
SB 218078是检查点激酶1（Chk1）的抑制剂，对其他蛋白激酶具有选择性（Chk1，cdc2和PKC的IC50值分别为15、250和1000 nM）。
化学数据
| 目录号 | A15480 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 393.39 |
| Formula | C24H15N3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 135897-06-2 |
| Synonyms | SB218078, SB-218078 |
| SMILES | C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.42 mL | 127.1 mL | 254.2 mL |
| 0.5 mM | 5.08 mL | 25.42 mL | 50.84 mL |
| 1 mM | 2.54 mL | 12.71 mL | 25.42 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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