6-Phosphogluconic acid trisodium 是一种有效的,竞争性磷酸葡萄糖异构酶 (PGI) 抑制剂,对 6-磷酸葡萄糖和 6-磷酸果糖的 Ki 值分别为 48 μM 和 42 μM。6-Phosphogluconic acid trisodium 是一种内源性代谢物 (endogenous metabolite)。
Cas No. |
53411-70-4 |
别名 |
6-磷酸葡萄糖酸三钠盐 |
分子式 |
C6H10Na3O10P |
分子量 |
342.08 |
储存条件 |
4°C, protect from light |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2]. 6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1]. [1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. |