| CAS NO: | 1245814-52-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1245814-52-1 |
| Canonical SMILES | O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC=C([N+]([O-])=O)S2 |
| 分子式 | C11H6F3N3O3S |
| 分子量 | 317.2 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | CAY10784 is a STAT3 inhibitor (IC50= 0.74 µM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 µM, respectively).2 1.LÜ, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitorsACS Med. Chem. Lett.(2021) 2.Ballard, T.E., Wang, X., Olekhnovich, I., et al.Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activityChemMedChem6(2)362-377(2011) |
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