生物活性
ACTB-1003是一种口服激酶抑制剂，靶向癌症突变（FGFR抑制），血管生成（抑制VEGFR2和Tie-2）并诱导凋亡（靶向PI3激酶下游的RSK和p70S6K。
化学数据
| 目录号 | A14431 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 591.53 |
| Formula | C27H26F5N7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 939805-30-8 |
| Synonyms | ACTB1003, ACTB 1003 |
| SMILES | COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.91 mL | 84.53 mL | 169.05 mL |
| 0.5 mM | 3.38 mL | 16.91 mL | 33.81 mL |
| 1 mM | 1.69 mL | 8.45 mL | 16.91 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.38 mL |
*The above data is based on the productmolecular weight 591.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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