SKF-80723 HBr is a D1 receptor agonist. In rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle, SKF-80723 HBr strongly potentiated the contralateral circling induced by quinpirole. References: Gnanalingham KK, Hunter AJ, Jenner P, Marsden CD. The differential behavioural effects of benzazepine D1 dopamine agonists with varying efficacies, co-administered with quinpirole in primate and rodent models of Parkinson's disease. Psychopharmacology (Berl). 1995 Feb;117(3):287-97. PubMed PMID: 7770604.
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CAS:71636-62-9