ITP-2 is a selective activator of hERG channels. ITP-2 causes large depolarizing shifts in the midpoint of voltage-dependent inactivation and hyperpolarizing shifts in the voltage-dependence of activation. References: Sale H, Roy S, Warrier J, Thangathirupathy S, Vadari Y, Gopal SK, Krishnamurthy P, Ramarao M. Modulation of K(v) 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator. Br J Pharmacol. 2017 Aug;174(15):2484-2500. doi: 10.1111/bph.13859. Epub 2017 Jun 18. PubMed PMID: 28500657; PubMed Central PMCID: PMC5513870.

纯度：≥98%

CAS：1428557-05-4