CI 972 is novel purine nucleoside phosphorylase inhibitor. It is a T cell-selective immunosuppressive agent. CI-972 inhibited proliferation of human MOLT-4 (T cell) but not MGL-8 (B cell) lymphoblasts with respective IC50s of 3.0 and greater than 50 microM when tested with 10 microM 2'-deoxyguanosine. References: Wilburn DJ, Dong MK, Gilbertsen RB. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR). Agents Actions. 1993;39 Spec No:C96-8. PubMed PMID: 8273599.

纯度：≥98%

CAS：115787-68-3