生物活性
PX-478 HCl是HIF-1alpha抑制剂，也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性，可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子，具有良好的i.v.，i.p.和p.o.抗肿瘤活性。
靶点信息
化学数据
| 目录号 | A14319 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 394.12 |
| Formula | C13H20Cl4N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 685898-44-6 |
| Synonyms | 0 |
| SMILES | C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl |
溶解度
| In vitro | DMSO | 73 mg/mL (185.21 mM) |
| Water | 73 mg/mL (185.21 mM) |
| Ethanol | 73 mg/mL (185.21 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.37 mL | 126.86 mL | 253.73 mL |
| 0.5 mM | 5.07 mL | 25.37 mL | 50.75 mL |
| 1 mM | 2.54 mL | 12.69 mL | 25.37 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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