High affinity BET bromodomain ligand
货号:ajcx27378
CAS:1809296-92-1
分子式:C23H21N5O3
分子量：415.44
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.

Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID:26367539